Regularization of the cell cycle, which is altered and uncontrolled in cancer. Lycopene has been shown to induce apoptosis in cancer cells. Epub 2017 Oct 7. 2014;6(2):466–488. It also helps to maintain a healthy function by exchanging old and non-functioning cells with new ones (8). Lycopene may show benefits against benign prostate hyperplasia. Lycopene has been identified as an antioxidant agent with potential anticancer properties. NLM Antioxidants protect the body from free radicals, which can result in oxidative stress. Tomatoes contain a powerful antioxidant called lycopene.It may help prostate cancer as well as reduce tumor growth among men with prostate preventcancer.  |  Herzog A, Siler U, Spitzer V, Seifert N, Denelavas A, Hunziker PB, Hunziker W, Goralczyk R, Wertz K. FASEB J. Lycopene also contains lipid antioxidant properties that aid in prostate health. This is very effective if we’re talking about a natural product that is affordable and easy to incorporate in your diet. A recent study showed that 10 servings of tomato every week is associated with a reduced risk of prostate cancer by 20% in the United Kingdom. World Cancer Research Fund International. They are triggered whenever the prostate increases its size. Lycopene is a natural product that has recently gained attention as an agent for prostate cancer prevention and treatment. Lycopene has been suggested to be beneficial for some eye disorders. What forms of Lycopene are easiest for the body to absorb? Lycopene did not interfere with normal prostate growth but seemed to modulate the expression of genes crucial to prostate health. It may also prevent the progression of the disease in cases of active benign prostatic hyperplasia (4). Early research suggests that lycopene may slow prostate enlargement in people with benign prostatic hypertrophy (BPH). Studies investigating the relation between lycopene and PCa risk have produced inconsistent results. Phase II randomized clinical trial of lycopene supplementation before radical prostatectomy. Get the latest public health information from CDC:, Get the latest research information from NIH:, Find NCBI SARS-CoV-2 literature, sequence, and clinical content: When the subjects consumed 8-16mg of the supplement for 12 weeks, the group suffered less severe skin reactions.  |  *DISCLAIMER: PLEASE NOTE THAT THIS WEBPAGE IS NOT INTENDED TO BE MEDICAL ADVICE. 75 (1), p54-60. However, there is not enough evidence to say that lycopene provides such health benefits. (2013). Lycopene is a powerful antioxidant carotenoid which is the source of the red coloring of tomatoes. Transcription factors are activated, new genes are made available, and new proteins are assembled. Prostate health is related to lifestyle and diet (1). SHOULD ALWAYS CONSULT YOUR MEDICAL PROFESSIONAL. Among the different benefits that lycopene has to offer, one of the most interesting to understand is how it modulates cell proliferation. If you want to consume more lycopene in your diet, chop and cook tomatoes instead of eating them fresh, this will contribute to the absorption of lycopene. 10 servings of tomato are equal to 10 cups of chopped tomatoes. Are there adverse effects of lycopene exposure?. for good", UK Tel:+44 (0) 845 According to a study, 10 servings of tomato, a week is enough to reduce your risk of prostate cancer (6). There are four reasons for this: Lycopene is a powerful antioxidant that has been shown to offer significant benefits for prostate health. It is a rather complex topic, but after short minutes of reading, you will understand what it’s all about. Instead, they replicate without any control. Cooperstone, JL; et al. National Center for Biotechnology Information, Unable to load your collection due to an error, Unable to load your delegates due to an error. Moreover, there are substances similar to vitamin A called carotenoids. The second line of evidence for the benefit of tomatoes is based on laboratory studies, on lab-grown cells and in animals. Whether lycopene itself or its metabolites induce most of its benefits is still uncertain. Click & discover the wonderful benefits of Lycopene > What causes BPH? 2020 Jan 29;18(1):43. doi: 10.1186/s12967-020-02238-7. Still, in these cases, there’s no hepatic dysfunction after using very high doses. Unlu, NZ; Bohn, T; Clinton, SK; Schwartz, SJ. Lycopene modulates several of the aforementioned pathways, providing a promising rationale for prostate cancer risk reduction by lycopene: In many experimental setups, lycopene reduced inflammatory signals, prevented oxidative DNA damage, modulated the expression or activity of IGF axis members, of Wnt/beta-catenin and androgen signalling, and enhanced gap junctional communication. However, oxidative damage in the DNA of prostate epithelial cells or any other cell line predisposes to the formation of prostate cancer cells. Would you like email updates of new search results? 2017 Feb;50(1):e12299. Lycopene is a carotenoid. Lycopene supplements and tomato-based products that contain lycopene are safe and well-tolerated. It also modulates the division and growth of prostatic tissue. Lycopene's influence on these pathways likely contributes to the observed cell growth inhibition and apoptosis induction by lycopene. COVID-19 is an emerging, rapidly evolving situation. Kaiser A, Haskins C, Siddiqui MM, Hussain A, D'Adamo C. Curr Opin Oncol. Lycopene shows antioxidant and anticancer properties. Lycopene Health Benefits Lycopene inhibits androgen receptor expression in prostate cancer cells in vitro and along with some of its metabolites, reduces prostate cancer cell proliferation and may modulate cell-cycle progression 23). Lycopene, a member … Please enable it to take advantage of the complete set of features! Lycopene is a constituent of human redox defence mechanism against free radicals.